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New England Journal of Medicin - Objets Actus

EARLY RELEASE: Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma
Mercredi 15 Octobre 2008 - 06:56 - 2 mois, 3 semaines depuis - Presse spécialisée - New England Journal of Medicin
Background A genomewide association study has shown an association between variants at chromosome 17q21 and an increased risk of asthma. To elucidate the relationship between this locus and disease, we ...

EARLY RELEASE: Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma
Mercredi 15 Octobre 2008 - 06:56 - 2 mois, 3 semaines depuis - Presse spécialisée - New England Journal of Medicin
Background It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk patients could receive novel interventional ...

EARLY RELEASE: Recurrence of Hepatocellular Carcinoma
Mercredi 15 Octobre 2008 - 06:56 - 2 mois, 3 semaines depuis - Presse spécialisée - New England Journal of Medicin
(No abstract is available for this citation)

EARLY RELEASE: 17q21 Variants and Asthma -- Questions and Answers
Mercredi 15 Octobre 2008 - 06:55 - 2 mois, 3 semaines depuis - Presse spécialisée - New England Journal of Medicin
(No abstract is available for this citation)

EARLY RELEASE: GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes
Mercredi 08 Octobre 2008 - 06:55 - 3 mois depuis - Presse spécialisée - New England Journal of Medicin
Background The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated GAD (GAD-alum) to ...

EARLY RELEASE: Immunotherapy on Trial for New-Onset Type 1 Diabetes
Mercredi 08 Octobre 2008 - 06:55 - 3 mois depuis - Presse spécialisée - New England Journal of Medicin
(No abstract is available for this citation)

EARLY RELEASE: Single Reading with Computer-Aided Detection for Screening Mammography
Mercredi 01 Octobre 2008 - 07:10 - 3 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
Background The sensitivity of screening mammography for the detection of small breast cancers is higher when the mammogram is read by two readers rather than by a single reader. We ...

ORIGINAL ARTICLE: Maraviroc for Previously Treated Patients with R5 HIV-1 Infection
Mercredi 01 Octobre 2008 - 06:55 - 3 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
The CCR5 coreceptor may be a therapeutic target to block HIV infection. HIV-1-infected patients who had received previous antiretroviral treatment were enrolled in one of two phase 3, placebo-controlled, double-blind international studies of treatment with maraviroc (a CCR5 antagonist). Maraviroc significantly lowered the HIV-1 viral load and increased the CD4 cell count at 48 weeks.

ORIGINAL ARTICLE: Subgroup Analyses of Maraviroc in Previously Treated R5 HIV-1 Infection
Mercredi 01 Octobre 2008 - 06:55 - 3 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
In key subgroups of the HIV-infected patients in the MOTIVATE 1 and MOTIVATE 2 studies, a consistent treatment benefit of maraviroc over placebo was seen at 48 weeks. These subgroups include patients with a low baseline CD4 cell count and a high HIV viral load at screening and those receiving no active background antiretroviral agents. In patients in whom maraviroc failed, the CXCR4-using virus was often present at failure.

ORIGINAL ARTICLE: Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration
Mercredi 01 Octobre 2008 - 06:55 - 3 mois, 1 semaine depuis - Presse spécialisée - New England Journal of Medicin
A variant of the toll-like receptor 3 (TLR3) provides protection against geographic atrophy, or "dry" age-related macular degeneration, and reduces apoptosis of cultured retinal pigment epithelial cells on exposure to TLR3 ligand. Because double-stranded RNA is a ligand of TLR3, this finding gives rise to the hypothesis that viral infection causes this disease and to concerns about therapeutic intraocular injection of short interfering RNA.

Actus fournies par : New England Journal of Medicine

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