ORIGINAL ARTICLE: Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis
Mercredi 22 Octobre 2008 - 06:55 - 2 mois, 2 semaines depuis
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Presse spécialisée
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New England Journal of Medicin
In this randomized, phase 2 trial involving previously untreated patients with early, relapsing-remitting multiple sclerosis, alemtuzumab, a monoclonal antibody targeting CD52 on lymphocytes and monocytes, was more effective than interferon beta-1a in reducing the progression of disability and relapse. Alemtuzumab caused autoimmune complications, including immune thrombocytopenic purpura (resulting in one death) and thyroid disorders.